Cogolludo, Ángel

Our group has more than 20 years of experience in the study of the physiological and pathological mechanisms involved in the regulation of vascular tone. One of our lines of research has focused on characterizing the effects of hypoxia (both acute and chronic) in several vascular beds. Specifically, we have identified the role of ceramide production (from neutral sphingomyelinase) and reactive oxygen species in hypoxic pulmonary vasoconstriction (HPV); a physiological mechanism that allows blood flow to the best ventilated areas of the lung, thereby improving ventilation-perfusion coupling. Another line of research in our group involves the study of vascular potassium channels and their regulation by physiological and pathological factors. Finally, our interest has also focused on identifying cellular and molecular mechanisms involved in the development of lung diseases, especially pulmonary hypertension and acute respiratory distress syndrome.